A study of Chinese consumers' online purchase intention based on Technology Acceptance Model and perceived risk

The widespread use of the Internet has promoted the development of e�commerce and electronic markets all around the world. The number of Internet users has increased rapidly in recent years, but the development of online shopping in China is not as good as expected. Hence, it is necessary to investigate the factors that impact Chinese consumers’ online shopping behavior. Consumers’ personal characteristics and perceived risks of online shopping are regarded as important influencing factors, as they may directly and indirectly influence consumers’ online purchasing behavior. However, few previous studies focused on investigating whether these factors impact Chinese consumers’ online shopping behavior simultaneously based on a reliable model. To analyze the impact that perceived risk in online shopping and characteristics has on the Chinese consumers’ online shopping behavior, the study develops an Extended Technology Acceptance Model that contains six dimensions of perceived risk, including social risk, psychological risk, performance risk, time risk, privacy risk, and financial risk, and three characteristics, which are gender, age, and the length of time on the Internet every week. The empirical analysis based on the results of 271 valid questionnaires show that perceived ease of use positively impacts perceived usefulness and attitude towards shopping online, perceived usefulness has a positive impact on attitude and intention to shop online, and attitude also positive influences shopping online intention. Regarding the perceived risk, six dimensions of it negatively impact perceived usefulness, attitude, and intention. Besides, it can be found that gender shows differences in perceived ease of use, perceived usefulness, social risk, and time risk. People who spend different time online every week vary in perceiving perceived usefulness, social risk, privacy risk, and performance risk. People of different ages perceive different levels of perceived usefulness, privacy risk, time risk, and financial risk. Furthermore, the study also provides Chinese online stores and relevant organizations with management implications and recommendations

Effect of a combination of Tuina therapy and budesonide inhalation on asthma in children, and its influence on lung function and pro inflammatory f actors

Purpose: To determine the effect of a combination of Tuina therapy and budesonide inhalation on pediatric asthma, and its influence on lung function and levels of inflammatory factors. Methods: Eligible 100 asthmatic children admitted to Provincial Maternity and Child-care Hospital, Lanzhou, Gansu Province, from January 2019 to January 2021 were randomized either to a control group or study group (1:1). The patients in control group were treated with budesonide inhalation, while the study group was given Tuina therapy in combination with budesonide inhalation. Treatment effectiveness, levels of inflammatory factors, immune functions and number of infections were evaluated in the patients. Results: The study group exhibited higher effectiveness profile versus the control group (96 vs 82 %; p < 0.05). After treatment, decreases were observed in the frequency of asthmatic attacks and number of respiratory infections in the two groups, with lower results in the study group than in the control group (p < 0.05). There were marked decreases in the levels of IgG, TNF-α and IL-8 in both groups, with the study group showing higher reductions (p < 0.05). Conclusion: Combined treatment with Tuina and budesonide inhalation decreases the levels of inflammatory factors, regulates immune function, and improves lung function of asthmatic children. Further investigation in a larger population would be required to establish the mechanism and clinical value of this therapy

Digital Predistortion of 75-110GHzW-Band Frequency Multiplier for Fiber Wireless Short Range Access Systems

We present a W-band fiber-wireless transmission system based on a nonlinear frequency multiplier for high-speed wireless short range access applications. By implementing a baseband digital signal predistortion scheme, intensive nonlinear distortions induced in a sextuple frequency multiplier can be effectively pre-compensated. Without using costly W-band components, a transmission system with 26km fiber and 4m wireless transmission operating at 99.6GHz is experimentally validated. Adjacent-channel power ratio (ACPR) improvements for IQ-modulated vector signals are guaranteed and transmission performances for fiber and wireless channels are studied. This W-band predistortion technique is a promising candidate for applications in high capacity wireless-fiber access systems

Y-DWMS - A digital watermark management system based on smart contracts

With the development of information technology, films, music, and other publications are inclined to be distributed in digitalized form. However, the low cost of data replication and dissemination leads to digital rights problems and brings huge economic losses. Up to now, existing digital rights management (DRM) schemes have been powerless to deter attempts of infringing digital rights and recover losses of copyright holders. This paper presents a YODA-based digital watermark management system (Y-DWMS), adopting non-repudiation of smart contract and blockchain, to implement a DRM mechanism to infinitely amplify the cost of infringement and recover losses copyright holders suffered once the infringement is reported. We adopt game analysis to prove that in Y-DWMS, the decision of non-infringement always dominates rational users, so as to fundamentally eradicate the infringement of digital rights, which current mainstream DRM schemes cannot reach

Revealing intrinsic domains and fluctuations of moir\'e magnetism by a wide-field quantum microscope

Moir\'e magnetism featured by stacking engineered atomic registry and lattice interactions has recently emerged as an appealing quantum state of matter at the forefront condensed matter physics research. Nanoscale imaging of moir\'e magnets is highly desirable and serves as a prerequisite to investigate a broad range of intriguing physics underlying the interplay between topology, electronic correlations, and unconventional nanomagnetism. Here we report spin defect-based wide-field imaging of magnetic domains and spin fluctuations in twisted double trilayer (tDT) chromium triiodide CrI3. We explicitly show that intrinsic moir\'e domains of opposite magnetizations appear over arrays of moir\'e supercells in low-twist-angle tDT CrI3. In contrast, spin fluctuations measured in tDT CrI3 manifest little spatial variations on the same mesoscopic length scale due to the dominant driving force of intralayer exchange interaction. Our results enrich the current understanding of exotic magnetic phases sustained by moir\'e magnetism and highlight the opportunities provided by quantum spin sensors in probing microscopic spin related phenomena on two-dimensional flatland

HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4+ T cell activation in Sjögren’s syndrome

Introduction: Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by exocrine gland dysfunction, leading to loss of salivary function. Histological analysis of salivary glands from SS patients reveals a high infiltration of immune cells, particularly activated CD4+ T cells. Thus, interventions targeting abnormal activation of CD4+ T cells may provide promising therapeutic strategies for SS. Here, we demonstrate that Hect, uba, and wwe domain containing 1 (HUWE1), a member of the eukaryotic Hect E3 ubiquitin ligase family, plays a critical role in CD4+ T-cell activation and SS pathophysiology.Methods: In the context of HUWE1 inhibition, we investigated the impact of the HUWE1 inhibitor BI8626 and sh-Huwe1 on CD4+ T cells in mice, focusing on the assessment of activation levels, proliferation capacity, and cholesterol abundance. Furthermore, we examined the therapeutic potential of BI8626 in NOD/ShiLtj mice and evaluated its efficacy as a treatment strategy.Results: Inhibition of HUWE1 reduces ABCA1 ubiquitination and promotes cholesterol efflux, decreasing intracellular cholesterol and reducing the expression of phosphorylated ZAP-70, CD25, and other activation markers, culminating in the suppressed proliferation of CD4+ T cells. Moreover, pharmacological inhibition of HUWE1 significantly reduces CD4+ T-cell infiltration in the submandibular glands and improves salivary flow rate in NOD/ShiLtj mice.Conclusion: These findings suggest that HUWE1 may regulate CD4+ T-cell activation and SS development by modulating ABCA1-mediated cholesterol efflux and presents a promising target for SS treatment

A study of Chinese consumers' online purchase intention based on Technology Acceptance Model and perceived risk

The widespread use of the Internet has promoted the development of e�commerce and electronic markets all around the world. The number of Internet users has increased rapidly in recent years, but the development of online shopping in China is not as good as expected. Hence, it is necessary to investigate the factors that impact Chinese consumers’ online shopping behavior. Consumers’ personal characteristics and perceived risks of online shopping are regarded as important influencing factors, as they may directly and indirectly influence consumers’ online purchasing behavior. However, few previous studies focused on investigating whether these factors impact Chinese consumers’ online shopping behavior simultaneously based on a reliable model. To analyze the impact that perceived risk in online shopping and characteristics has on the Chinese consumers’ online shopping behavior, the study develops an Extended Technology Acceptance Model that contains six dimensions of perceived risk, including social risk, psychological risk, performance risk, time risk, privacy risk, and financial risk, and three characteristics, which are gender, age, and the length of time on the Internet every week. The empirical analysis based on the results of 271 valid questionnaires show that perceived ease of use positively impacts perceived usefulness and attitude towards shopping online, perceived usefulness has a positive impact on attitude and intention to shop online, and attitude also positive influences shopping online intention. Regarding the perceived risk, six dimensions of it negatively impact perceived usefulness, attitude, and intention. Besides, it can be found that gender shows differences in perceived ease of use, perceived usefulness, social risk, and time risk. People who spend different time online every week vary in perceiving perceived usefulness, social risk, privacy risk, and performance risk. People of different ages perceive different levels of perceived usefulness, privacy risk, time risk, and financial risk. Furthermore, the study also provides Chinese online stores and relevant organizations with management implications and recommendations